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杰出校友华东理工大学教授、留美学者曾步兵

曾步兵个人主页
姓名 曾步兵 性别
Email zengbb@ecust.edu.cn 职称
联系电话 021-64253689 邮编 200237
通信地址 上海市梅陇路130号

职务(学术团体兼职)

研究领域
与研究方向
1. 开展具有抗肿瘤生理活性的天然产物全合成; 2. 活性天然产物类似物的合成和构效关系研究;
个人简介
1997年9月至2000年7月 中国科学院上海有机化学研究所生命有机国家重点实验室有机化学专业,获博士学位;导师: 吴毓林教授和吴厚铭教授 1994年9月至1997年7月 中国药科大学药学院药物化学专业, 获硕士学位;导师: 廖清江教授 1990年9月至1994年7月 青岛化工学院应用化学系工业分析专业, 获学士学位。高邮市第一中学高中毕业.
主要成果(教学获奖,发表论文,出版教材、专著、参考书,荣誉称号及其他获奖等)
1. Bu-Bing Zeng, Yikang Wu, Qian Yu, Yu-Lin Wu,etc. Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumors Cell Lines, Angew. Chem. Int. Ed. 2001,1934-1937. 2. Sheng Jiang, Zhong-Hai Liu, Gang Shen, Bu-Bing Zeng, Xiao-guang Chen, Yu-Lin Wu, and Zhu-Jun Yao, Mimicry of Annonaceous Acetogenins: Enantioselective Synthesis of a (4R)-Hydroxy Analogue Having Potent Antitumor Activity. J. Org. Chem., 2002,3404-3408. 3. Bu-Bing Zeng, Bruce S. King Palladium-Catalyzed Synthesis of Water-Soluble Symmetric 9,10-Distituted Anthracenes, Synthesis, 2002, 2335-2337. 4. Bu-Bing Zeng, Yikang Wu, and Yu-Lin Wu, etc. Studies on Mimicry of Naturally Occurring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity against Human Tumor Cells. Chem. Eur. J., 2003,282-290. 5. Andrew D. Cohen, Bu-Bing Zeng, S. Bruce King, and John P. Toscano. Direct Observation of an Acyl Nitroso Species in Solution by Time-Resolved IR Spectrocopy. J. Am. Chem. Soc., 2003,1444-1445. 6. Bu-Bing Zeng, Jinming Huang, Marcus Wright and S. Bruce King, Synthesis and Evaluation of Water Soluble N-Hydrooxyurea derived Acyl Nitroso-9, 10-Dimethylanthracene Cycloadducts as Nitroxyl (HNO) Donors, Bioorg. & Med. Chem. Lett. 2004, 5565-5568. 7. Lee, A. M.; Ross, C. T.; Zeng, B.-B.; Singleton, S. F. A Molecular Target for Suppression of the Evolution of Antibiotic Resistance: Inhibition of the Escherichia coli RecA Protein by N6-(1-Naphthyl)-ADP. J. Med. Chem.; 2005; 5408-5411.
教学工作(开设课程,教书育人等)
开设课程: 1.药物化学 2.药物分析 3.波谱解析
科研工作(科研项目名称/项目来源/年份,在研课题等)
1.抗前列腺癌活性的番荔枝内酯4-Hydroxytrilobin 的全合成研究 上海市科委 2005.09-2007.12 2.抗前列腺癌活性的番荔枝内酯4-Hydroxytrilobin 的类似物合成研究 教育部 2006.01-2007.12
曾步兵 教授

联系电话:021-6425-3846

E-mail: bubingzeng_ecust at yahoo.com.cn

博士-------中国科学院上海有机化学研究所 (2000)

博士后----Wake Forest 大学化学系 (2001-2004)

UNC at Chapel Hill 药学院 (2004-2005)




研究方向

开展具有抗肿瘤生理活性的天然产物全合成及类似物的合成和构效关系研究。

 

近期发表文章

1. Bu-Bing Zeng, Yikang Wu, Qian Yu, Yu-Lin Wu, etc. Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumors Cell Lines, Angew. Chem. Int. Ed. 2001, 39(11), 1934-1937.

2. Yu-Lin Wu, Wen-Lian Wu, Zhu-Jun Yao, Yun-Long Li, Y.-F. Wang, Jing-Cui Li, Xiao-Ling Sun, Zhi-Hui Peng, Qian Yu, Tai-Shan Hu, Bu-Bing Zeng, Xiang-Zhu Wang, Synthesis of Chiral Pure Natural Prodducts from Carbohydrates, Chinese Journal of Organic Chemistry, 2001, 21(11), 1051-1059

3. Sheng Jiang, Zhong-Hai Liu, Gang Shen, Bu-Bing Zeng, Xiao-guang Chen, Yu-Lin Wu, and Zhu-Jun Yao, Mimicry of Annonaceous Acetogenins: Enantioselective Synthesis of a (4R)-Hydroxy Analogue Having Potent Antitumor Activity. J. Org. Chem., 2002, 67, 3404-3408.

4. Bu-Bing Zeng, Tai-Shan Hu, Wei Yun, Yikang Wu, Yu-Lin Wu. Strsightforward Synthesis of Two Pairs of Enantiomeric Butenolides 3-Tetradecyl- and 3-Hexadecyl-5-Methyl-2(5H)-Furanone. Enantiomer, 2002, 7(2-3), 133-137.

5. Bu-Bing Zeng, Bruce S. King Palladium-Catalyzed Synthesis of Water-Soluble Symmetric 9,10-Distituted Anthracenes, Synthesis, 2002, 2335-2337.

6. Bu-Bing Zeng, Yikang Wu, and Yu-Lin Wu, etc. Studies on Mimicry of Naturally Occurring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity against Human Tumor Cells. Chem. Eur. J., 2003, 9(1), 282-290.

7. Andrew D. Cohen, Bu-Bing Zeng, S. Bruce King, and John P. Toscano. Direct Observation of an Acyl Nitroso Species in Solution by Time-Resolved IR Spectrocopy. J. Am. Chem. Soc., 2003, 125, 1444-1445.

8. Bu-Bing Zeng Tai-Shan Hu, Chun Xu, Yu-Zhu Fang, Hou-Ming, Wu, Yu-Lin Wu. Studies towards the Complexation of Bis-THF Annonaceous Acetogenins Analogs and Annonacin With Calcium Ion, Acta Chimica Sinica, 2003, 1140-1143.

9. Bu-Bing Zeng, Jinming Huang, Marcus Wright and S. Bruce King, Synthesis and Evaluation of Water Soluble N-Hydrooxyurea derived Acyl Nitroso-9, 10-Dimethylanthracene Cycloadducts as Nitroxyl (HNO) Donors, Bioorg. & Med. Chem. Lett. 2004